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Bradford Hill Criteria

  1. Temporal relationship (Concurrence): after MMR II change

  2. Dose Response: MMR II, varicella,
    Hepatitis A

  3. Biological Plausibility:
         A. HH-DNA - preferentially incorporated →  Human DNA
         B. Chromosomal Mutations
         C. Mutations inheritable, not inherited

  4. Strength of Association: # of CNV changes

  5. Coherence (see 3A)

  6. Analogy: Cadaver GH

  7. Consistency: similar ASD rates in Europe, Asia, N. America

  8. Specificity: of population- need large group of vaccine refusers (? Amish)

               No other likely explanation

  9. Experiment